300 m after you leave the Rhodos airport there is a traffic light. Turn right in the direction towards Falilaki-Lindos.
This will take you onto the Rhodos-Faliraki-Lindos highway. When you arrived in Faliraki drive inside the village and turn left in the Rhodos town direction. This should be followed for about 5 minutes.
Follow this road for about 2.5 km till you see the Louis Colossos Hotel on your right.